Cartilage resurfacing of the rabbit knee: The use of an allogeneic demineralized bone matrix-autogeneic perichondrium composite implant
- 1 January 1990
- journal article
- research article
- Published by Medical Journals Sweden AB in Acta Orthopaedica
- Vol. 61 (3), 201-206
- https://doi.org/10.3109/17453679008993501
Abstract
A full-thickness articular-cartilage defect was created in the medial femoral condyles of 32 adult rabbits. The defects were filled with demineralized bone or a composite of demineralized bone and perichondrium. Results of cartilage repair were assessed after 12 weeks of implantation. We conclude that demineralized bone matrix used as a subchondral matrix in a cartilage repair model 1) stimulates and induces subchondral bone ingrowth, 2) provides a surface on which cartilage repair can proceed, and 3) can be utilized as a platform on which perichondrium can be fixed to provide a cellular source for cartilage repair. Repair tissue that developed from perichondrium was thicker, more closely resembled normal articular cartilage, and was of a less fibrous nature than the repair tissue that developed de novo on the demineralized bone matrix.This publication has 16 references indexed in Scilit:
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