A quantitative study of the anticholinergic action of several tricyclic antidepressants on the rat isolated fundal strip
Open Access
- 19 July 1972
- journal article
- Published by Wiley in British Journal of Pharmacology
- Vol. 45 (3), 519-524
- https://doi.org/10.1111/j.1476-5381.1972.tb08109.x
Abstract
1 Investigations were carried out on the antagonism of the action of carbamylcholine chloride on the isolated fundus of the rat stomach by several tricyclic antidepressants. 2 The anticholinergic potency of the compounds was in the order: GP 45437>amitriptyline>protriptyline>desmethylimipramine>opipramol. All of the antagonists were less effective than atropine. 3 Statistical analysis was carried out to determine whether the theory of competitive antagonism would fit the data obtained.Keywords
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