ANTICONVULSANT COMPOUNDS AND 5‐HYDROXY‐TRYPTAMINE IN RAT BRAIN
Open Access
- 1 June 1957
- journal article
- Published by Wiley in British Journal of Pharmacology and Chemotherapy
- Vol. 12 (2), 228-231
- https://doi.org/10.1111/j.1476-5381.1957.tb00125.x
Abstract
In rats, a series of anticonvulsant compounds have been shown to cause a significant elevation of brain 5-hydroxytryptamine (5-HT) levels in comparison with control values. This increase in 5-HT only occurred in brain tissue and was not observed in spleen, upper small intestine or blood. Elevation of brain levels of 5-HT by iproniazid (Marsilid) or 5-hydroxytryptophan failed to give protection against the convulsant or lethal action of lept zol (75 mg./kg.).Keywords
This publication has 6 references indexed in Scilit:
- Diphenylhydantoin and Brain-Levels of 5-HydroxytryptamineNature, 1956
- USE OF MEPROBAMATE (MILTOWN) IN CONVULSIVE AND RELATED DISORDERSJAMA, 1956
- THE USE OF SOME MOLLUSCAN HEARTS FOR THE ESTIMATION OF 5‐HYDROXYTRYPTAMINEBritish Journal of Pharmacology and Chemotherapy, 1955
- The distribution of substance P and 5‐hydroxytryptamine in the central nervous system of the dogThe Journal of Physiology, 1954
- Serotonin Content of Some Mammalian Tissues and Urine and a Method for Its DeterminationAmerican Journal of Physiology-Legacy Content, 1953