Effect of renal function on risedronate pharmacokinetics after a single oral dose

Abstract

To determine the relationship between risedronate pharmacokinetics and renal function. Risedronate was administered to adult men and women (n=21) with various degrees of renal function (creatinine clearance 15-126 ml min-1 ) as a single oral dose of 30 mg. Serum samples were obtained for 72 h after dosing, and urine samples were collected for 72 h after dosing and then periodically for 6 weeks. Risedronate concentrations were determined using an enzyme-linked immunosorbent assay (ELISA). Risedronate serum concentration-time and urinary excretion rate-time profiles were analysed simultaneously using nonlinear regression. Renal clearance and volume of distribution were linearly related to creatinine clearance (r2=0.854, P20 ml min-1 ).