THE EFFECT OF REPEATED INJECTIONS OF EPINEPHRIN ON THE RESISTANCE OF SUPRARENALECTOMIZED RATS TO HISTAMIN POISONING

Abstract

Epinephrine administered subcutaneously twice daily for 7 days following suprarenal-ectomy affords protection to rats against lethal doses of histamine in 50% of cases. If epinephrine is discontinued 24 hrs. before histamine injection its protective action is markedly decreased and an injection 2 hrs. previous to histamine affords no protection. The protective action is believed to be due, in part, to a true hormonal effect and not entirely to a pharmacological antagonistic action of epinephrine to histamine.