Can satellite glial cells be therapeutic targets for pain control?
- 1 February 2010
- journal article
- Published by Cambridge University Press (CUP) in Neuron Glia Biology
- Vol. 6 (1), 63-71
- https://doi.org/10.1017/s1740925x10000098
Abstract
Satellite glial cells (SGCs) undergo phenotypic changes and divide the following injury into a peripheral nerve. Nerve injury, also elicits an immune response and several antigen-presenting cells are found in close proximity to SGCs. Silencing SCG-specific molecules involved in intercellular transport (Connexin 43) or glutamate recycling (glutamine synthase) can dramatically alter nociceptive responses of normal and nerve-injured rats. Transducing SGCs with glutamic acid decarboxylase can produce analgesia in models of trigeminal pain. Taken together these data suggest that SGCs may play a role in the genesis or maintenance of pain and open a range of new possibilities for curing neuropathic pain.Keywords
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