Cerebral Vasodilators

Abstract

Drugs Acting on AdrenoreceptorsIsoxsuprine Pharmacology Isoxsuprine is a phenylethylamine derivative of epinephrine. The compound is said to be an alpha-adrenoreceptor antagonist with beta-adrenoreceptor-stimulating properties, but the vasodilator effects on muscle blood flow are not prevented by beta-adrenoreceptor blockade.⁷⁸ The drug also lowers blood viscosity and inhibits platelet aggregation when given in high doses.⁷⁹ Effect on Cerebral Blood Flow Intravenous isoxsuprine produces both cerebral and peripheral vasodilatation. A fall in blood pressure occurs and is not fully compensated by the decrease in cerebrovascular resistance; a small reduction in cerebral blood flow results.^{29,51, 80} Effect on Cerebrovascular Disease and Dementia Three double-blind, . . .