Transformation of Hamster Cells In Vitro by Polycyclic Hydrocarbons without Cytotoxicity
- 1 December 1971
- journal article
- research article
- Published by Proceedings of the National Academy of Sciences in Proceedings of the National Academy of Sciences
- Vol. 68 (12), 2958-2961
- https://doi.org/10.1073/pnas.68.12.2958
Abstract
Treatment with either a flavone or benz(α)anthracene before the addition of a potent carcinogen, benzo(α)pyrene or 3-methylcholanthrene, enhanced the transformation of Syrian hamster cells that are seeded in order to form colonies. 7,8-benzoflavone and benz(α)anthracene prevented the cytotoxicity by the carcinogens, while 5,6-benzoflavone did not. The results clearly indicate that it is possible to dissociate the transforming from the toxic metabolic properties of benzo(α)pyrene and 3-methylcholanthrene.Keywords
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