Renin responses to water restriction and rehydration
- 1 October 1972
- journal article
- Published by Wiley in The Journal of Physiology
- Vol. 226 (1), 1-13
- https://doi.org/10.1113/jphysiol.1972.sp009970
Abstract
1. The effect of restricted water intake and rapid rehydration was studied in three conscious sheep with respect to plasma renin concentration (PRC), blood corticosteroid levels, plasma protein and electrolyte concentrations, and the renal and faecal excretion of sodium and potassium.2. During water restriction the plasma concentrations of renin, protein and sodium rose while aldosterone levels were low or undetectable. Plasma potassium levels were unchanged. External sodium and potassium balance appeared to be unaffected.3. During rehydration the sheep drank more than their estimated water deficit in 3-4 min with the following effects: PRC rose three- to fourfold during the ensuing 12 hr. Aldosterone levels too rose, while plasma protein, sodium and potassium concentrations fell. Urinary sodium excretion virtually ceased for 24 hr, and urine flow rate increased only little during this period.4. If there was a single stimulus to renin release during water restriction and rehydration, it was not an alteration in vascular or extravascular volume, total body sodium, systemic B.P. or plasma sodium concentration.5. It is concluded that the rise in PRC in these experiments is compatible with the theory that altered sodium transport at the macula densa was the stimulus for renin release.Keywords
This publication has 26 references indexed in Scilit:
- RENIN LEVELS IN THE KANGAROO, THE WOMBAT AND OTHER MARSUPIAL SPECIESJournal of Endocrinology, 1971
- THE EFFECT OF ADRENAL ARTERIAL INFUSION OF HYPERTONIC NaHCO3 SOLUTION ON ALDOSTERONE SECRETION IN SODIUM DEFICIENT SHEEPActa Endocrinologica, 1971
- Mechanism of the Effects of Furosemide on Renin Secretion in Anesthetized DogsCirculation Research, 1969
- Renal innervation and renin activity in salt metabolism and hypertensionAmerican Journal of Physiology-Legacy Content, 1969
- Measurement of Aldosterone in Peripheral Blood of Man and Sheep1Journal of Clinical Endocrinology & Metabolism, 1967
- THE RENIN/ANGIOTENSIN‐ALDOSTERONE SYSTEM IN SODIUM DEPLETIONThe Medical Journal of Australia, 1967
- Control of renin release.Physiological Reviews, 1967
- Inhibition of Renin Release by Vasopressin and AngiotensinCardiovascular Research, 1967
- Neural Stimulation of Release of ReninCirculation Research, 1966
- RENIN-ANGIOTENSIN SYSTEM, ALDOSTERONE, AND SODIUM BALANCE.1965