REDUCTION OF GRANULOSA CELL PROGESTERONE SECRETIONIN VITROBY INTRAOVARIAN IMPLANTS OF ANTIANDROGEN
- 1 March 1978
- journal article
- research article
- Published by The Endocrine Society in Endocrinology
- Vol. 102 (3), 984-987
- https://doi.org/10.1210/endo-102-3-984
Abstract
Intraovarian Silastic implants containing the antiandrogen, flutamide, or its active metabolite [SCH 16423; .alpha., .alpha., .alpha.-trifluoro-2-methyl-4''-nitro-m-lactotoluidide], reduced the level of progesterone secretion in porcine granulosa cell cultures by approximately 50%. These results complement recent observations in vitro suggesting a role for androgen in granulosa cell steroidogenesis during follicular development.This publication has 9 references indexed in Scilit:
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