The synthesis of pyrrolo[1,2-a]quinoxalines from N-(2-acylaminophenyl)pyrroles

Abstract

N-(2-Acylaminophenyl)pyrroles undergo ready cyclisation to pyrrolo[1,2-a]quinoxalines. The parent heterocycle is quaternised at the 5-nitrogen with methyl iodide, and on treatment with potassium amide yields 4-amino-pyrrolo[1,2-a]quinoxaline.