Persistence of Inhibitory Activity against Normal Bone-Marrow Cells during Remission of Acute Leukemia
- 16 August 1979
- journal article
- research article
- Published by Massachusetts Medical Society in New England Journal of Medicine
- Vol. 301 (7), 346-351
- https://doi.org/10.1056/nejm197908163010702
Abstract
Bone-marrow cells from patients with acute leukemia in remission were tested for their capacity to produce a substance (leukemia-associated inhibitory activity, LIA) that inhibits the formation of granulocyte and macrophage colonies in cultures of normal, but not of leukemic, bone marrow. LIA was detected in extracts of whole marrow in only eight of 83 patients in remission. However, extracts of slowly sedimenting cells, separated by velocity sedimentation from the marrows of eight patients in remission whose whole marrow had produced no LIA, produced inhibitory material in all cases. Extracts of the more rapidly sedimenting cells from these marrows contained an inactivator of LIA.This publication has 28 references indexed in Scilit:
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