Spatial Overlap of on and off Subregions and Its Relation to Response Modulation Ratio in Macaque Primary Visual Cortex

Abstract

We studied the spatial overlap of on and off subregions in macaque primary visual cortex and its relation to the response modulation ratio (the F₁/F₀ ratio). Spatial maps of on and off subregions were obtained by reverse correlation with a dynamic noise pattern of bright and dark spots. Two spatial maps, on and off, were produced by cross-correlating the spike train with the location of bright and dark spots in the stimulus respectively. Several measures were used to assess the degree of overlap between subregions. In a subset of neurons, we also computed the F₁/F₀ ratio in response to drifting sinusoidal gratings. Significant correlations were found among all the overlap measures and the F₁/F₀ ratio. Most overlap indices considered, and the F₁/F₀ measure, had bimodal distributions. In contrast, the distance between on and off subregions normalized by their size was unimodal. Surprisingly, a simple model that additively combines on and off subregions with spatial separations drawn from a unimodal distribution, can readily explain the data. These analyses clarify the relationship between subregion overlap and the F₁/F₀ ratio in macaque primary visual cortex, and a simple model provides a parsimonious explanation for the co-existence of bimodal distributions of overlap indices and a unimodal distribution of the normalized distance.