Plasma calcium distribution in relation to parathyroid function
- 1 February 1961
- journal article
- research article
- Published by American Physiological Society in American Journal of Physiology-Legacy Content
- Vol. 200 (2), 341-344
- https://doi.org/10.1152/ajplegacy.1961.200.2.341
Abstract
The plasma calcium was fractionated into protein-bound and free fractions by means of an ultracentrifuge in normal, hypoparathyroid and hyperparathyroid dogs and normal and hypoparathyroid rats. The proportion of the total plasma calcium that was diffusible was greater in normal and hypercalcemic animals than in the hypoparathyroid state. Recalcification of hypoparathyroid dog plasma in vitro gave a similar calcium distribution to that obtained when parathyroid extract was injected into hypoparathyroid dogs. Although the binding of calcium per gram of plasma protein increased both in vivo and in vitro as the concentration rose, the results did not conform to the simple mass law relationship as usually expressed. The evidence presented indicates that parathyroid function only influences the distribution of plasma calcium indirectly by regulating its concentration.This publication has 7 references indexed in Scilit:
- THE ULTRAFILTRABLE CALCIUM OF HUMAN SERUM. II. VARIATIONS IN DISEASE STATES AND UNDER EXPERIMENTAL CONDITIONS1JCI Insight, 1958
- Casein: Monomers and Polymers1Journal of the American Chemical Society, 1955
- The calcium binding of human serum albumin in health and diseaseBiochemical Journal, 1953
- ULTRAFILTRATION STUDIES ON CALCIUM AND PHOSPHORUS IN PATHOLOGICAL HUMAN SERUM1953
- A Simplified Photometric Method for the Determination of Citric Acid in Biological FluidsJournal of Biological Chemistry, 1952
- THE APPLICATION OF THE LAW OF MASS ACTION TO BINDING BY PROTEINS - INTERACTIONS WITH CALCIUM1946
- THE RELATION OF THE PARATHYROID HORMONE TO THE STATE OF CALCIUM IN THE BLOODAmerican Journal of Physiology-Legacy Content, 1935