PLASMA VOLUME OF DOGS IN DEHYDRATION, WITH AND WITHOUT SALT LOSS 1

Abstract

Reductions in body water with and without accompanying salt loss, were produced experimentally in dogs. Plasma volumes were detd. by use of the dye T-1824 and from the blood volume as measured by the distribution of CO. Changes in volume of the extracellular and intracellular fluid were also detd. The results indicated that changes in plasma volume parallel those in extracellular fluid volume only under certain limited conditions, and depletion of extracellular salt and water results in a more severe circulatory embarrassment than can be attributed to the contraction in extracellular fluid volume alone.