Dynamic Studies of Growth Hormone and Prolactin Secretion in the Female Rat

Abstract

Blood samples were removed via chronic intra-atrial cannulae every 15 min in female rats during the estrous cycle, the last week of pregnancy, parturition and suckling. Growth hormone (GH) secretion during the estrous cycle is characterized by episodic release, occurring approximately once hourly. The surges in GH increase during the last 3–4 days of gestation, and rise to high levels during delivery and with suckling. Prolactin (PRL) shows minimal fluctuations during the estrous cycle, except for a prominent pulsatile surge during proestrus. PRL rises 4–6 h prior to parturition and declines during delivery. These studies provide a basis for further studies on the dynamics of GH and PRL secretion in the female rat.