SIDE REACTIONS IN PEPTIDE-SYNTHESIS .9. SUPPRESSION OF THE FORMATION OF AMINOSUCCINYL PEPTIDES WITH ADDITIVES
- 1 January 1978
- journal article
- research article
- Vol. 12 (5), 277-283
Abstract
The base-catalyzed ring closure of .beta.-benzylaspartyl peptides was efficiently suppressed by the addition of phenols with electron-withdrawing substituents to the reaction mixtures. Of a series of compounds tested, 2,4-dinitrophenol and pentachlorophenol were the most effective. No direct relationship was found between the acidity of the additives and their ability to suppress the formation of aminosuccinyl peptides. The applicability of 2,4-dinitrophenol and pentachlorophenol in practical syntheses was examined.This publication has 3 references indexed in Scilit:
- SIDE REACTIONS IN PEPTIDE-SYNTHESIS .6. RE-EXAMINATION OF BENZYL GROUP IN PROTECTION OF SIDE-CHAINS OF TYROSINE AND ASPARTIC-ACID1978
- SIDE REACTIONS IN PEPTIDE-SYNTHESIS .7. SEQUENCE DEPENDENCE IN FORMATION OF AMINOSUCCINYL DERIVATIVES FROM BETA-BENZYL-ASPARTYL PEPTIDES1978
- Synthesis and pharmacological properties of the N-terminal decapeptide of the vasoactive intestinal peptide (VIP)Journal of Medicinal Chemistry, 1977