Studies on Immunity in Experimental Syphilis: I. IMMUNOLOGIC RESPONSE OF RABBITS IMMUNIZED WITH REITER PROTEIN ANTIGEN AND CHALLENGED WITH VIRULENT TREPONEMA PALLIDUM
Open Access
- 1 September 1963
- journal article
- research article
- Published by BMJ in Sexually Transmitted Infections
- Vol. 39 (3), 195-198
- https://doi.org/10.1136/sti.39.3.195
Abstract
The authors attempted to determine the clinical and serologic response of rabbits immunized with the serologically active protein antigen extracted by D''Allessandro from the Reiter strain (RP), and then challenged with virulent T. pallidum. 18 of the 19 rabbits immunized over a 5 week period with a total of 3.25 ml of sterile, serologically-active RP antigen developed dark-field positive lesions upon challenge, and only 1 rabbit was considered immune. No significant difference between the immunized and control rabbits was observed in the size of the lesions or in the duration of the incubation period. Both reagin and TPI antibodies failed to develop during immunization. Most of the rabbits were seroreactive to the TPCF antigen, but there was no significant rise after attempts at immunization. The RPCF titer on the other hand rose abruptly within 2 weeks after the initiation of immunization. The presence of this RPCF antibody did not protect the rabbits from syphilitic infection on challenge.Keywords
This publication has 13 references indexed in Scilit:
- ANTIGENICITY IN RABBITS AND RELATION TO IMMUNITY1962
- The Demonstration of a Common Antigen in Reiter's Treponeme and Virulent Treponema PallidumThe Journal of Immunology, 1959
- Investigations into the antigenic structure of the Reiter strain ofTreponema pallidumAntonie van Leeuwenhoek, 1958
- [Proteinic antigens of Treponema: demonstration of an antigen common to pathogenic Treponema and to the Reiter's protein of culturable Treponema].1957
- IMMUNOLOGIC STUDIES WITH FRACTIONS OF VIRULENT TREPONEMA PALLIDUM .1. PREPARATION OF AN ANTIGEN BY DESOXYCHOLATE EXTRACTION AND ITS USE IN COMPLEMENT FIXATION1955
- A simple medium for maintaining the viability of Treponema pallidum in the Treponema pallidum immobilization test.1954
- Isolation and purification of the protein antigen of the Reiter treponeme; a study of its serologic reactions.1953
- Further attempts to immunize rabbits with killed Treponema pallidum.1951
- IMMUNOLOGICAL RELATIONSHIPS AMONG SPECIES AND STRAINS OF VIRULENT TREPONEMES AS DETERMINED WITH THE TREPONEMAL IMMOBILIZATION TEST123American Journal of Epidemiology, 1951
- THE ANTIBODY RESPONSE IN RABBITS TO KILLED SUSPENSIONS OF PATHOGENIC T. PALLIDUMThe Journal of Experimental Medicine, 1948