Immunosuppressive treatment in multifocal motor neuropathy
- 1 September 1991
- journal article
- case report
- Published by Wiley in Annals of Neurology
- Vol. 30 (3), 397-401
- https://doi.org/10.1002/ana.410300312
Abstract
We report the results of immunosuppressive treatments of 13 patients with multifocal motor neuropathy and elevated titers of serum antibodies to the GM1 ganglioside. All patients failed to respond to oral prednisone. There was no clinical response in 4 patients treated with plasma exchange. Nine patients received cyclophosphamide, with clinical improvement and fall in antibody titers in 8. In 3 patients, cyclophosphamide was discontinued with ensuing clinical relapse and rise in the titers of serum anti‐GM1 antibodies. These patients provide further evidence for the efficacy of cyclophosphamide therapy in patients with multifocal motor neuropathy.Keywords
This publication has 18 references indexed in Scilit:
- The spectrum of neurologic disease associated with anti‐GM 1 antibodiesNeurology, 1990
- Polyclonal IgM anti‐GM1 ganglioside antibody in patients with motor neuron disease and variantsAnnals of Neurology, 1990
- Lower motor neuron syndromes defined by patterns of weakness, nerve conduction abnormalities, and high titers of antiglycolipid antibodiesAnnals of Neurology, 1990
- A syndrome of asymmetric limb weakness with motor conduction blockNeurology, 1990
- A treatable multifocal motor neuropathy with antibodies to GM1 gangliosideAnnals of Neurology, 1988
- Motor neuron syndrome and monoclonal IgM with antibody activity against gangliosides GM1 and GD1bAnnals of Neurology, 1988
- Multifocal acquired demyelinating neuropathy masqurading as motor neuron diseaseMuscle & Nerve, 1988
- Motor neuron disease and plasma cell dyscrasiaNeurology, 1986
- Gangliosides GM1 and GD1b are antigens for IgM M-protein in a patientwith motor neuron diseaseNeurology, 1986
- Multifocal demyelinating neuropathy with persistent conduction blockNeurology, 1982