Ganglionic Blocking Action of Dimethylphenyl-Piperazinium (DMPP)

Abstract

Dimethylphenylpiperazinium iodide (DMPP) blocks transmission of preganglionic nerve impulses at the superior cervical ganglion of the cat. This effect is augmented by subsequent addition of acetylcholine. It also depresses the emptying reaction, but has no effect on the longitudinal muscle contraction, caused by transmural stimulation of the guinea pig ileum. DMPP appears to block transmission in the same way as does tetramethylammonium, and large doses of acetylcholine.