Cloning and sequence analysis of cDNA for bovine adrenal preproenkephalin
- 1 January 1982
- journal article
- research article
- Published by Springer Nature in Nature
- Vol. 295 (5846), 202-206
- https://doi.org/10.1038/295202a0
Abstract
The nucleotide sequence of cloned cDNA for preproenkephalin from bovine adrenal medulla indicates that the precursor protein contains four copies of Met-enkephalin and one copy each of Leu-enkephalin, Met-enkephalin-Arg6 -Phe7 and Met-enkephalin-Arg6 -Gly7 -Leu8, a previously undetected opioid peptide. The enkephalin and extended enkephalin sequences are each bounded by paired basic amino acid residues. Preproenkephalin may represent a multi-hormone precursor, like the corticotropin-β-lipotropin precursor.Keywords
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