Apigenin: A Promising Molecule for Cancer Prevention
Top Cited Papers
- 20 March 2010
- journal article
- review article
- Published by Springer Science and Business Media LLC in Pharmaceutical Research
- Vol. 27 (6), 962-978
- https://doi.org/10.1007/s11095-010-0089-7
Abstract
Apigenin, a naturally occurring plant flavone, abundantly present in common fruits and vegetables, is recognized as a bioactive flavonoid shown to possess anti-inflammatory, antioxidant and anticancer properties. Epidemiologic studies suggest that a diet rich in flavones is related to a decreased risk of certain cancers, particularly cancers of the breast, digestive tract, skin, prostate and certain hematological malignancies. It has been suggested that apigenin may be protective in other diseases that are affected by oxidative process, such as cardiovascular and neurological disorders, although more research needs to be conducted in this regard. Human clinical trials examining the effect of supplementation of apigenin on disease prevention have not been conducted, although there is considerable potential for apigenin to be developed as a cancer chemopreventive agent.Keywords
This publication has 146 references indexed in Scilit:
- Apigenin suppresses insulin‐like growth factor I receptor signaling in human prostate cancer: An in vitro and in vivo studyMolecular Carcinogenesis, 2008
- Plant flavonoid apigenin inactivates Akt to trigger apoptosis in human prostate cancer: an in vitro and in vivo studyCarcinogenesis: Integrative Cancer Research, 2008
- Apigenin inhibits antiestrogen-resistant breast cancer cell growth through estrogen receptor-α-dependent and estrogen receptor-α-independent mechanismsMolecular Cancer Therapeutics, 2008
- Flavonoids and ovarian cancer risk: A case–control study in ItalyInternational Journal of Cancer, 2008
- Apigenin-induced prostate cancer cell death is initiated by reactive oxygen species and p53 activationFree Radical Biology & Medicine, 2008
- Apigenin Prevents UVB-Induced Cyclooxygenase 2 Expression: Coupled mRNA Stabilization and Translational InhibitionMolecular and Cellular Biology, 2007
- Molecularly targeted agents: Their promise as cancer chemopreventive interventionsEuropean Journal Of Cancer, 2005
- Beer constituents as potential cancer chemopreventive agentsEuropean Journal Of Cancer, 2005
- Flavonoids: antioxidants or signalling molecules?Free Radical Biology & Medicine, 2004
- Cancer chemoprevention with dietary phytochemicalsNature Reviews Cancer, 2003