p53-Mediated Upregulation of BAX Gene Transcription Is Not Involved in Bax-α Protein Overexpression in the Left Ventricle of Spontaneously Hypertensive Rats
- 1 June 1999
- journal article
- other
- Published by Wolters Kluwer Health in Hypertension
- Vol. 33 (6), 1348-1352
- https://doi.org/10.1161/01.hyp.33.6.1348
Abstract
—An association of increased apoptosis with overexpression of the proapoptotic protein Bax-α has been reported in the left ventricle of adult spontaneously hypertensive rats (SHR). Both alt...Keywords
This publication has 13 references indexed in Scilit:
- Losartan inhibits the post-transcriptional synthesis of collagen type I and reverses left ventricular fibrosis in spontaneously hypertensive ratsJournal Of Hypertension, 1999
- Stretch-mediated release of angiotensin II induces myocyte apoptosis by activating p53 that enhances the local renin-angiotensin system and decreases the Bcl-2-to-Bax protein ratio in the cell.Journal of Clinical Investigation, 1998
- Myocyte cell death and ventricular remodelingCurrent Opinion in Nephrology and Hypertension, 1997
- Myocyte death in heart failureCurrent Opinion in Cardiology, 1996
- Chromosomal assignment of the Bcl2-related genes, Bcl2l and Bax, in the mouse and ratCytogenetic and Genome Research, 1996
- Overexpression of the Bcl-2 Protein Increases the Half-life of p21BaxPublished by Elsevier ,1995
- Expression cloning of cardiotrophin 1, a cytokine that induces cardiac myocyte hypertrophy.Proceedings of the National Academy of Sciences, 1995
- Tumor suppressor p53 is a direct transcriptional activator of the human bax geneCell, 1995
- BH1 and BH2 domains of Bcl-2 are required for inhibition of apoptosis and heterodimerization with BaxNature, 1994
- Regulation of the Cryptic Sequence-specific DNA-binding Function of p53 by Protein KinasesCold Spring Harbor Symposia on Quantitative Biology, 1994