Drug Delivery Issues in Vaccine Development
- 1 January 1996
- journal article
- review article
- Published by Springer Nature in Pharmaceutical Research
- Vol. 13 (12), 1777-1785
- https://doi.org/10.1023/a:1016064504346
Abstract
Although significant headway has been made in vaccine development, there are several delivery-related issues that must be overcome to advance tomorrow's candidate vaccines. Some of these are in the areas of: single-shot subunit vaccines, therapeutic vaccines for cancer, the use of cytokines as vaccine adjuvants, DNA-based vaccines, and the development of vaccines that provide sterilizing immunity, as might be required for an affective HIV-1 prophylactic vaccine. The hurdles for vaccine advancement in these areas are briefly described.Keywords
This publication has 94 references indexed in Scilit:
- Antibodies to Schistosoma Japonicum (Asian Bloodfluke) Paramyosin Induced by Nucleic Acid VaccinationBiochemical and Biophysical Research Communications, 1995
- DNA vaccines: A novel approach to immunizationInternational Journal of Immunopharmacology, 1995
- Protection against malaria by immunization with a Plasmodium yoelii circumsporozoite protein nucleic acid vaccineVaccine, 1994
- Vaccine technologies: view to the futureScience, 1994
- Lymphocyte responses and cytokinesCell, 1994
- Cancer vaccinesImmunology Today, 1993
- Transport Protein Genes in the Murine MHC: Possible Implications for Antigen ProcessingScience, 1990
- Isolation and analysis of naturally processed viral peptides as recognized by cytotoxic T cellsNature, 1990
- Isolation of an endogenously processed immunodominant viral peptide from the class I H–2Kb moleculeNature, 1990
- Immunizations: Current controversiesThe Journal of Pediatrics, 1982