Effects of Interparticulate Interactions on Mixing Homogeneity

Abstract

By theoretical approach, the highest degree of mixing of cohesive, interactive powders was derived to conform to the homogeneity of the random mixture of free-flowing, non-interactive constituents. Particulate interactions like adherence of a cohesive drug ingredient to the diluent component, cannot yield ordered mixtures of higher degree of homogeneity under real mixing conditions. These conclusions were confirmed by mixing experiments, using minor proportions of free-flowing and of cohesive drug constituents, and diluents in excess. With both types of drug powders, the quality of the random mixture was attained. Ordered mixtures of higher degree of homogeneity could not be produced.