Binding of Drugs to Serum Albumin

Abstract

Competition between Drugs for Albumin BindingConcomitantly administered drugs can influence one another's binding to serum albumin, other serum proteins or tissue proteins. Interaction at the tissue level is difficult to study, and its clinical importance remains unknown. Since some drugs are extensively localized in tissues (e.g., tricyclic antidepressants, diazepam, quinidine, phenothiazines) their displacement from these sites by other drugs could be quantitatively very important.Drug binding to serum albumin can be decreased or enhanced by other drugs, but no clinically important examples of the latter are known. In contrast, there are many drugs that partially displace one another from . . .