Mouse retinoic acid receptor alpha 2 isoform is transcribed from a promoter that contains a retinoic acid response element.
- 15 November 1991
- journal article
- research article
- Published by Proceedings of the National Academy of Sciences in Proceedings of the National Academy of Sciences
- Vol. 88 (22), 10138-10142
- https://doi.org/10.1073/pnas.88.22.10138
Abstract
We have characterized the promoter of the mouse retinoic acid receptor alpha 2 (mRAR-alpha 2) isoform. This promoter contains a retinoic acid response element (RARE) that closely resembles the RARE that is present in the RAR-beta 2 promoter. Moreover, RAR-alpha 2 and RAR-beta 2 proximal promoter sequences are similar to each other and generate transcripts whose respective start sites are located at similar positions. The RAR-alpha 2 RARE consists of two directly repeated 5'-GTTCA-3' motifs to which all three RARs (alpha, beta, and gamma) bind in vitro.Keywords
This publication has 17 references indexed in Scilit:
- Retinoic acid response element in the human alcohol dehydrogenase gene ADH3: implications for regulation of retinoic acid synthesis.Molecular and Cellular Biology, 1991
- Multiple isoforms of the mouse retinoic acid receptor alpha are generated by alternative splicing and differential induction by retinoic acid.The EMBO Journal, 1991
- Activation of the ovalbumin gene by the estrogen receptor involves the Fos-Jun complexCell, 1990
- A Retinoic Acid Receptor-Specific Element Controls the Retinoic Acid Receptor-β PromoterMolecular Endocrinology, 1990
- Identification of a retinoic acid responsive element in the retinoic acid receptor & beta;geneNature, 1990
- Site-specific mutagenesis using asymmetric polymerase chain reaction and a single mutant primerNucleic Acids Research, 1990
- Characterization of a functional promoter for the human retinoic acid receptor-alpha (hRAR-α)Nucleic Acids Research, 1990
- Cloning of murine α and β retinoic acid receptors and a novel receptor γ predominantly expressed in skinNature, 1989
- Use of restriction enzymes to detect potential gene sequences in mammalian DNANature, 1987
- CAT constructions with multiple unique restriction sites for the functional analysis of eukaryotic promoters and regulatory elementsNucleic Acids Research, 1987