Acetylator phenotyping: A comparison of the isoniazid and dapsone tests
- 1 January 1981
- journal article
- research article
- Published by Springer Nature in European Journal of Clinical Pharmacology
- Vol. 20 (3), 233-234
- https://doi.org/10.1007/bf00544604
Abstract
A comparison was made between the results of acetylator phenotyping by isoniazid (INH) half-life measurements based on 5 samples (0–6 h), and by determination of the ratio of monoacetylated (MAD) to unchanged dapsone (DDS) in a single sample obtained 3 h after dapsone intake. In each of 44 subjects examined, there was unequivocal agreement about classification of the subject as a rapid (INH t1/2 0.3) or slow (INH t1/2 >2 h; MAD/DDS <0.3) acetylator. It appears that the single-sample (3 h) dapsone test is as reliable as the more laborious and time-consuming INH test for acetylator phenotyping.Keywords
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