The purine and pyrimidine composition of some deoxyribonucleic acids from tumours
- 1 February 1954
- journal article
- research article
- Published by Portland Press Ltd. in Biochemical Journal
- Vol. 56 (2), 349-352
- https://doi.org/10.1042/bj0560349
Abstract
Specimens of deoxypentose nucleic acids (DNA) were prepd. by standard procedures from spontaneous and exptlly. induced animal tumors and some from human cancers. The purine and pyrimidine composition was detd. by hydrolysis with perchloric acid, chromato-graphic separation on filter paper, and measurement by u.-v. spectroscopy. The ratios of adenine to guanine and of thymine to cytosine were greater than 1 in all specimens, DNA resembling DNA from noncancerous animal tissues. The most significant deviation was the low thymine value of mouse-sarcoma DNA.Keywords
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