Whole blood angiopoietin-1 and -2 levels discriminate cerebral and severe (non-cerebral) malaria from uncomplicated malaria
Open Access
- 15 December 2009
- journal article
- research article
- Published by Springer Nature in Malaria Journal
- Vol. 8 (1), 295
- https://doi.org/10.1186/1475-2875-8-295
Abstract
Severe and cerebral malaria are associated with endothelial activation. Angiopoietin-1 (ANG-1) and angiopoietin-2 (ANG-2) are major regulators of endothelial activation and integrity. The aim of this study was to investigate the clinical utility of whole blood angiopoietin (ANG) levels as biomarkers of disease severity in Plasmodium falciparum malaria.Keywords
This publication has 18 references indexed in Scilit:
- Serum Angiopoietin-1 and -2 Levels Discriminate Cerebral Malaria from Uncomplicated Malaria and Predict Clinical Outcome in African ChildrenPLOS ONE, 2009
- Angiopoietin-2 is associated with decreased endothelial nitric oxide and poor clinical outcome in severe falciparum malariaProceedings of the National Academy of Sciences, 2008
- Plasma IP-10, apoptotic and angiogenic factors associated with fatal cerebral malaria in IndiaMalaria Journal, 2008
- Angiopoietin-2 is increased in severe sepsis: Correlation with inflammatory mediatorsCritical Care Medicine, 2007
- Evaluation of rapid diagnostic tests: malariaNature Reviews Microbiology, 2006
- Human cerebral malaria and the blood–brain barrierInternational Journal for Parasitology, 2006
- Excess Circulating Angiopoietin-2 May Contribute to Pulmonary Vascular Leak in Sepsis in HumansPLoS Medicine, 2006
- The global distribution of clinical episodes of Plasmodium falciparum malariaNature, 2005
- Development of a Real-Time PCR Assay for Detection of Plasmodium falciparum , Plasmodium vivax , and Plasmodium ovale for Routine Clinical DiagnosisJournal of Clinical Microbiology, 2004
- Severe falciparum malariaTransactions of the Royal Society of Tropical Medicine and Hygiene, 2000