Nuclear matrix–DNA complex resulting fromEcoR1 digestion of HeLa nucleoids is enriched for DNA replicating forks
- 1 January 1983
- journal article
- Published by Oxford University Press (OUP) in Nucleic Acids Research
- Vol. 11 (7), 2155-2164
- https://doi.org/10.1093/nar/11.7.2155
Abstract
Upon treatment of HeLa nucleoids with EcoR1 restriction enzyme, a minute fraction of the DNA remains attached to the nuclear matrix. This matrix-DNA complex appears to be composed of a unique set of proteins. Electron microscopic analysis of the DNA fragments present shows an enrichment for HeLa DNA replicating forks.ImagesKeywords
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