Facile synthesis of 3-(aminomethyl)isoquinolines by copper-catalysed domino four-component coupling and cyclisation
- 1 January 2008
- journal article
- Published by Royal Society of Chemistry (RSC) in Chemical Communications
- No. 7,p. 835-837
- https://doi.org/10.1039/b718201e
Abstract
Copper(I)-catalysed domino four-component coupling–cyclisation using 2-ethynylbenzaldehydes, paraformaldehyde, secondary amine, and t-BuNH2 in DMF leads to direct and efficient formation of 3-(aminomethyl)isoquinolines in good to high yields.Keywords
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