Blood Coagulation and Platelet Function following Maximal Exercise: Effects of Beta-Adrenoceptor Blockade
- 1 January 1984
- journal article
- research article
- Published by S. Karger AG in Pathophysiology of Haemostasis and Thrombosis
- Vol. 14 (3), 262-268
- https://doi.org/10.1159/000215067
Abstract
Alterations of platelet function and blood coagulation may occur with exercise or β-adrenoceptor blockade. To determine if β-blockade could modify exercise-induced changes in haemostatic factors we performed a double-blind study of actue strenuous exercise in normal males with and without β-blockade. Exercise increased prostacyclin and plasminogen activator levels but there was no evidence of thrombin generation as indicated by unchanged platelet aggregation responses, β-thromboglobulin and íibrinopeptide A levels. The only alteration in coagulation by β-blockade was a reduction in the factor VIII:C and VIII:RAg rise after exercise and this modification may be relevant to the protective effect of these drugs in patients with coronary artery disease.Keywords
This publication has 7 references indexed in Scilit:
- The β-blocker heart attack trial: studies of platelets and factor VIIIThrombosis Research, 1982
- Comparison of platelet function during exercise in normal subjects and coronary artery disease patients:Potential role of platelet activation in myocardial ischemiaAmerican Heart Journal, 1982
- Some Observations on the Release of Extrinsic and Intrinsic Plasminogen Activators during Exercise in ManPathophysiology of Haemostasis and Thrombosis, 1980
- Lack of fibrin formation in exercise-induced activation of coagulationAmerican Journal of Physiology-Heart and Circulatory Physiology, 1979
- The fibrinolytic response of man to vasoactive drugs measured in arterial bloodThrombosis Research, 1978
- Turnover of fibrinogen, plasminogen, and prothrombin during exercise in manJournal of Applied Physiology, 1977
- Fibrinolytic and hemostatic changes during and after maximal exercise in malesJournal of Applied Physiology, 1976