Steady-state kinetic formalism applied to multienzyme complexes, oxidative phosphorylation, and interacting enzymes.
- 1 December 1976
- journal article
- research article
- Published by Proceedings of the National Academy of Sciences in Proceedings of the National Academy of Sciences
- Vol. 73 (12), 4432-4436
- https://doi.org/10.1073/pnas.73.12.4432
Abstract
A kinetic formalism, quite generally valid for free energy transducing, steady-state, macromolecular systems in biology, is applied here to multienzyme complexes, oxidative phosphorylation and interacting enzymes. Systems of this type, comprising several interacting subunits, each with its own discrete set of states, present no new features in principle. Hence, they may be handled by the earlier kinetic formalism without modification. The kinetic diagram can become quite complicated because the state of each subunit (enzyme) must be specified in order to specify any 1 state of the system (complex) as a whole. Cycles, forces, fluxes, free energy levels and state probabilities are considered.This publication has 13 references indexed in Scilit:
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