Industrializing Structural Biology
- 20 July 2001
- journal article
- Published by American Association for the Advancement of Science (AAAS) in Science
- Vol. 293 (5529), 519-520
- https://doi.org/10.1126/science.293.5529.519
Abstract
X-ray crystallography is the method of choice for determining molecular structure. The accumulation of molecular structure information has allowed a more complete representation of three-dimensional protein folds, enabling more successful homology modeling of unknown structures. Breakthroughs in genome sequencing projects have underscored the need for concomitant advances in structural biology if we hope to determine the extent of protein folding-space and elucidate how an assembly of proteins constitutes a cellular organism. This essay outlines an industrial approach to high-throughput (HT) determination of molecular structures.Keywords
This publication has 27 references indexed in Scilit:
- From Genome to FunctionScience, 2001
- Recognition of Cognate Transfer RNA by the 30 S Ribosomal SubunitScience, 2001
- Crystal Structure of the Ribosome at 5.5 Å ResolutionScience, 2001
- The Complete Atomic Structure of the Large Ribosomal Subunit at 2.4 Å ResolutionScience, 2000
- Architecture of RNA Polymerase II and Implications for the Transcription MechanismScience, 2000
- The technology that enables synchrotron structural biologyNature Structural & Molecular Biology, 1998
- Crystal Structure of the 20 S Proteasome from the Archaeon T. acidophilum at 3.4 Å ResolutionScience, 1995
- Structure of the protein subunits in the photosynthetic reaction centre of Rhodopseudomonas viridis at 3Å resolutionNature, 1985
- Structure of Myoglobin: A Three-Dimensional Fourier Synthesis at 2 Å. ResolutionNature, 1960
- X-Ray Photographs of Crystalline PepsinNature, 1934