The absorption from the gut of quinine and chlorpheniramine given with various anionic agents

Abstract

The absorption of quinine and chlorpheniramine with anionic agents was examined in the rat rectum, small intestine and stomach. The enhancement of absorption was related to partition behaviour, to the organic solvent, and surface activity of ion-pair complexes, but it seems that with results from these properties alone it is not possible to explain the apparent increase in the in situ absorption of amines. In the presence of anionic agents, the absorption of amines was enhanced at all sites examined and kinetically the uptake to the mucosal membrane was increased in the rectum and small intestine. The effect of anionic agents on the uptake of amines was greater in the rectum than in the small intestine and this may be related to differences in the nature of the gut wall.