Serum Carnitine
- 1 March 1973
- journal article
- research article
- Published by American Medical Association (AMA) in Archives of Neurology
- Vol. 28 (3), 186-190
- https://doi.org/10.1001/archneur.1973.00490210066009
Abstract
Carnitine was identified as a constituent of normal human serum by reaction with a specific enzyme and by thin-layer chromatography. A spectrophotometric enzymatic assay was adapted for use with human serum, based upon the liberation of coenzyme A from acetylcoenzyme A in the presence of carnitine and carnitine acetyltransferase. Normal human serum contains 2.3μmols to 7.0μmols/100ml. Serum content increased to 33.4μmols/100 ml during attacks of myoglobinuria but was not increased in patients with Duchenne dystrophy, liver disease, uremia, or acute myocardial infarction.Keywords
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