Inhibition of gastric emptying in mice by bacterial endotoxins
- 1 December 1963
- journal article
- research article
- Published by American Physiological Society in American Journal of Physiology-Legacy Content
- Vol. 205 (6), 1113-1116
- https://doi.org/10.1152/ajplegacy.1963.205.6.1113
Abstract
Mice injected with bacterial endotoxins exhibit a rapid reduction of food and water intake, to a degree dependent on the magnitude of the dose. Using phenol red solution as a tracer, it has been demonstrated that gastric emptying is inhibited by endotoxin injection; that the effect is rapid (within 10–15 min); and that it occurs whether the endotoxin is injected intraperitoneally or intravenously. With four different endotoxin preparations, inhibition is maximal at one-tenth of the ld50. Significant inhibition may be caused by between 1/20 and 1/100 of an ld50, depending on the preparation used. Injection of cortisone acetate reduces the inhibition of gastric emptying caused by endotoxin injection; intravenously injected Proferrin, however, does not increase the response, although it sensitizes the mouse to the lethal effects of endotoxin.Keywords
This publication has 9 references indexed in Scilit:
- The Effect of Environmental Temperature on the Host-Parasite Relationship in MiceThe Journal of Infectious Diseases, 1962
- THE EFFECT OF BACTERIAL ENDOTOXINS ON THE WATER INTAKE AND BODY WEIGHT OF MICEThe Journal of Experimental Medicine, 1961
- EFFECTS OF BACTERIAL ENDOTOXINS ON METABOLISMThe Journal of Experimental Medicine, 1961
- EFFECTS OF BACTERIAL ENDOTOXIN ON METABOLISMThe Journal of Experimental Medicine, 1959
- EFFECTS OF BACTERIAL ENDOTOXIN ON METABOLISMThe Journal of Experimental Medicine, 1959
- Mechanics and Regulation of Gastric EmptyingPhysiological Reviews, 1957
- The simultaneous measurement of absorption and transit in the gastro‐intestinal tract of the ratThe Journal of Physiology, 1956
- The Use of Ranks in a Test of Significance for Comparing Two TreatmentsBiometrics, 1952
- DEPRESSION OF GASTRIC MOTILITY WITHOUT ELEVATION OF BODY TEMPERATURE FOLLOWING THE INJECTIONS OF PYROGENSAmerican Journal of Physiology-Legacy Content, 1942