The Action in vitro and in vivo of Sodium Versenate on the Phagocytic Activity of Neutrophile Leukocytes

Abstract

In vitro, the viability of granulocytes as measured by the capacity of digesting carbonyl iron is abolished by disodium versenate. Most probably, this is a function of an altered cell membrane potential, since at the same time artificially induced clumping of the granulocytes was lowered. The same dose (mg Na2 EDTA/ml plasma), sometimes used clinically, does not influence the phagocytic capacity of the granulocytes when given intravenously as infusion.