ERK-Dependent Modulation of Cerebellar Synaptic Plasticity after Chronic Δ9-Tetrahydrocannabinol Exposure
Open Access
- 24 May 2006
- journal article
- Published by Society for Neuroscience in Journal of Neuroscience
- Vol. 26 (21), 5810-5818
- https://doi.org/10.1523/jneurosci.5469-05.2006
Abstract
Chronic exposure to Δ9-tetrahydrocannabinol (THC) induces tolerance to cannabinoid-induced locomotor effects, which are mediated by cannabinoid receptors (CB1Rs) located in motor control regions, including the cerebellum. There is substantial evidence of cerebellar CB1R molecular adaptation and modifications in receptor signaling after prolonged cannabinoid exposure. However, very little is known about the effects of chronic cannabinoid administration on cerebellar synaptic plasticity, which may contribute to the development of cannabinoid behavioral tolerance.Keywords
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