Antioxidants in neoplastic cells: II. Isolation and partial characterization of a phenolic antioxidant from differentiated mouse neuroblastoma cells

Abstract

The generation of an antioxidant has been shown to be associated with the dramatic increase in resistance to lipid peroxidation which occurs during the differentiation of mouse neuroblastoma cells in culture. The antioxidant has been isolated from the neuroblastoma neutral lipid fraction and partially characterized by means of low-resolution and high-resolution mass spectrometry and other lines of evidence. All presently available information suggests that this antioxidant is a highly aromatic, monosubstituted phenol having the molecular formula C₁₉H₁₄O₂.