Osteomyelitis

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Abstract
Known since antiquity,1 osteomyelitis is a difficult-to-treat infection characterized by the progressive inflammatory destruction and new apposition of bone.24 This review focuses on current knowledge of the disease and the progress being made in understanding its pathogenesis, diagnosis, and treatment.PathogenesisThe pathogenesis of osteomyelitis has been explored in various animal models5; these studies have found that normal bone is highly resistant to infection, which can only occur as a result of very large inocula, trauma, or the presence of foreign bodies.6,7 Certain major causes of infection, such as Staphylococcus aureus, adhere to bone by expressing receptors . . .