STUDIES CONCERNING DOPAMINE DIURESIS IN RAT

Abstract

Dopamine is both diuretic and saluretic in the conscious rat. The diuretic effect does not appear to be .beta.-receptor mediated, but rather may be the result of a combination of .alpha.- and dopaminergic receptor stimulation. Conclusive proof for the existence of the latter must await the discovery of a more selective peripheral dopamine-receptor stimulant than is dopamine per se.