RELATIVE INCREASE IN CHLORIDE EXCRETION IN THE DOG AFTER GRADUATED DOSES OF MERCURIAL DIURETICS

Abstract

In a series of trained, unanesthetized dogs the range of dosage between beginning tubular inhibition and the maximum chloride excretion varied for each mercurial diuretic. This range was suggested as a means of evaluating these diuretics. Within a range of dosage of 0.5-2.5 mg. Hg/kg., Salyrgan produced a maximum Cl excretion of approx. 200 mg. NaCl/10 min./ 10 kg. of dog. Esidrone (0.5 to 3.0 mg. Hg/kg.) produced a maximum excretion of 300 mg. NaCl, and Mercupurin (0.5 to 6.0 mg. Hg/kg.) produced a maximum excretion of 500 mg. NaCl.