QUANTITATIVE STUDIES ON THE MIXED LYMPHOCYTE INTERACTION IN RATS

Abstract

The proliferative interaction of cultured rat lymphocytes of immunogenetically disparate origin—the mixed lymphocyte interaction—was employed as an experimental model to examine the initial stages of the immune response mechanism. Using mixed cultures of cells derived from parental strain and F₁ hybrid rats, in which only the parental lymphocytes respond, the following observations were made on the magnitude and kinetics of the reaction.