Bradykinin potentiating and sensitizing activities of new synthetic analogs of snake venom peptides

Abstract

The structural requirements for prolonged residual (sensitizing) activity in bradykinin-potentiating peptides (BPP) [Agkistrodon halys blomhoffii and Bothrops jararaca] were investigated through a study of 7 synthetic BPP including 3 not previously described: [Lys6]-BPP9a, [Gly6]potentiator B and [Lys6,Gln8]potentiator B. The quantitation of the sensitizing activities in the isolated guinea pig ileum indicated that the structural requirements for bradykinin potentiation and for sensitization were not the same. The most potent sensitizers were potentiator B and [Lys6]-BPP9a.