HYDROGEN-ION STUDIES. VII. EXPERIMENTAL NEPHRITIS IN RABBITS WITH MONOBASIC SODIUM PHOSPHATE

Abstract

Many studies of experimental nephritis are reported in the literature, notably those which concern the injection of the salts of the heavy metals, uranium and tartrates, into rabbits and dogs. There seems to be no mention of nephritis caused by the injection into rabbits of relatively large amounts of monobasic sodium phosphate. In the course of certain experiments with rabbits, injections of solutions of this salt were made and in the examination of the kidney tissue, necrosis of the cells lining the convoluted tubules and the loops of Henle was observed. Other experiments were made to confirm this observation, and in each instance depending in severity largely on the length of time that the rabbit was poisoned by the injections, there are necrotic changes in the cells of the renal tubules mentioned. Blood to be used for determining the hydrogen ion concentration and the carbon dioxid combining power was drawn