Occurrence of Tumors in Wild House Mice
- 1 May 1962
- journal article
- research article
- Published by Oxford University Press (OUP) in JNCI Journal of the National Cancer Institute
- Vol. 28 (5), 1153-1163
- https://doi.org/10.1093/jnci/28.5.1153
Abstract
The occurrence of spontaneous tumors in wild house mice (Mus musculus) raised in captivity is recorded. All tumors included herein were visible on gross examination. A total of 225 mice was necropsied, of which 98, or 43.5 percent, had developed tumors. A total of 121 tumors was found, of which 44, or 36 percent, were in 107 mice from 2 to 24 months of age, and 77, or 64 percent, were in 118 mice from 25 to 33 months of age. Incidences of the most frequent tumors found were: pulmonary, 21 percent; reticulum-cell (type B), 10 percent; granulosa-cell of ovary, 5 percent; hepatomas, 5 percent; hemangioendotheliomas, 4 percent. Ninety-nine breeding females showed a mammary-tumor incidence of 6 percent; no mammary tumors were found in 72 nonbreeding females. Only 2 unquestionable lymphocytic neoplasms were found. One arose subcutaneously in the dorsal cervical region, and the other was in the thymus gland and was spreading beyond the capsule.Keywords
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