Control of genioglossus muscle inspiratory activity
- 1 November 1980
- journal article
- research article
- Published by American Physiological Society in Journal of Applied Physiology
- Vol. 49 (5), 801-808
- https://doi.org/10.1152/jappl.1980.49.5.801
Abstract
Tonic and phasic inspiratory genioglossus (GG) electromyographic activity (EMG) was recorded from 13 anesthetized rabbits during unstimulated breathing. Integrated GG EMG peaked earlier in inspiration and presented a more rounded contour than integrated diaphragmatic (DIA) EMG. Spontaneous augmented deep inspirations (sighs) showed a biphasic pattern in both GG and DIA EMGs. Hyperventilation abolished phasic inspiratory activity in the GG before the DIA, suggesting that the GG has a higher CO2 apneic point. Hypercapnia increased both EMGs; however, GG EMG increased more, as a percent of base line, than did DIA EMG. Oxygen breathing decreased GG more than DIA EMG; sodium cyanide injection and brief nitrogen breathing increased GG more than DIA EMG; carotid body denervation abolished these responses. Vagotomy abolished the Hering-Breuer inflation-inhibition reflex in both muscles, and tactile, visual, and auditory stimulation increased GG more than DIA EMG. Thus, the GG responses to chemoreceptor input and to nonspecific respiratory stimuli are qualitatively similar but quantitatively different from DIA responses. The relevance to mixed and obstructive apnea is discussed.This publication has 11 references indexed in Scilit:
- Mixed and Obstructive Sleep Apnea and Near Miss for Sudden Infant Death Syndrome: 2. Comparison of Near Miss and Normal Control Infants by AgePediatrics, 1979
- A neuromuscular mechanism maintaining extrathoracic airway patencyJournal of Applied Physiology, 1979
- Sleep Apnea, Hypopnea and Oxygen Desaturation in Normal SubjectsNew England Journal of Medicine, 1979
- Obstructive Sleep Apnea in Family MembersNew England Journal of Medicine, 1978
- Pathogenesis of upper airway occlusion during sleepJournal of Applied Physiology, 1978
- Hypoventilation During Sleep in Children Who Have Lymphoid Airway Obstruction Treated by Nasopharyngeal Tube and T and APediatrics, 1977
- Changes in respiratory frequency and end-expiratory volume accompanying augmented breaths in catsPflügers Archiv - European Journal of Physiology, 1976
- The human tongue during sleep: Electromyographic activity of the genioglossus muscleExperimental Neurology, 1976
- A new bipolar electrode for electromyographyJournal of Applied Physiology, 1962
- Upper airway obstruction in the unconscious patientJournal of Applied Physiology, 1959