MODE OF ACTION OF ANTITHYROID COMPOUNDS

1 April 1950

journal article
research article
Published by American Physiological Society in Physiological Reviews

Vol. 30 (2), 194-205
https://doi.org/10.1152/physrev.1950.30.2.194

Abstract

Literature principally since 1947 is reviewed: inhibition of the iodine-concentrating mechanism of the thyroid by thiocyanate; inhibition of thyroxine synthesis by iodides, p-aminobenzoic acid, sulfonamides, thiourea, thiouracils, aminothiazoles, 2-mercaptoimidazoles, and possibly thiocyanate; inhibition of thyroid activity through tissue destruction by radioactive I isotopes.

Keywords

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